Synthesis, Physico-chemical, Spectral and X-ray Diffraction Studies of Zn(II) Complex of Pioglitazone - A New Oral Antidiabetic Drug

Present paper deals with the synthesis, spectral characterization and X-ray diffraction study of Zn(II) complex with Pioglitazone a new oral antidiabetic drug. The conductometric titration using monovariation method indicate that complex is ionic and L2M type which was further confirmed by Job’s method of continuous variation as modified by Turner and Anderson. Analytical data agree with the molecular formula of complex viz. [(C19H19N2O3S) + 2 Zn]2Cl -. Structure of complex was assigned as tetrahedral, in which ligand molecules lies horizontally joining the central Zn(II) atom, supported by IR, 1H NMR and Mass studies. X-ray diffraction data also supports the complex formation and symmetry of complex. key words: Pioglitazone, antidiabetic drug, complex, IR, 1H NMR, Mass and X-ray diffraction. but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. It exhibits slow gastrointestinal absorption rate and inter individual variation of its bioavailability3. A survey of literature reveals that metal complexes of many drugs have been found to be more effective than the drug alone4 therefore, much attention is given to the use of thiazolidinedione hydrochloride due to their high complexing nature with essential metals. Fig.2 shows the enolization nature of complex formation . Zinc is an essential trace metal, so we get it through the food we eat. Next to iron, zinc is most common mineral in the body and is found in every plant and animal cell.5 It has been used since ancient times to heal wounds 1080 PRAKASH et al., Orient. J. Chem., Vol. 29(3), 1079-1084 (2013) and plays an important role in the immune system, reproduction, growth, vision, blood clotting, proper insulin and thyroid function6-7 Chelates of streptomycin are obtained by adding aqueous solutions of zinc salts to the solution of streptomycin at pH 9.0 (loc.cit). Zinc complex of sulpha drugs have been prepared and studied by Salil et al.,8 Bipin et al.,9 Sharma et al., 10 Iqbal and co-workers 11-13 and compare the antidiabetic properties of zinc complex with the parent drugs. Fig.1: Structure of Pioglitazone HCl Fig. 2: Enolized structure for complex formation